Mechanisms of calcium phosphates formation on inorganic nanomaterials
A biomimetic synthetic route for multifunctional nanocomposites for hard tissue regeneration
she there held a lecture titled Influence of BSA on formation of calcium phosphates and silver nanoparticles composites.
The Workshop was held from 12. to 13. December 2022 at Hotel Brdo, Brdo pri Kranju in Slovenia.
Here is the abstract of her lecture:
The study was published on 2 December 2022 in open access. You can read the whole article on this link:
Minerals | Free Full-Text | Influence of Biomacromolecules on Calcium Phosphate Formation on TiO2 Nanomaterials (mdpi.com)
The abstract of the publication is here:
Calcium phosphates (CaP) composites with biomacromolecules and/or nanomaterials have recently emerged as a potential solution to improve the poor mechanical properties and biological response of CaP. Among the methods available for preparation of such composites, precipitation at low temperatures attracts special interest as it allows preservation of the activity of biomacromolecules. However, precipitation of CaP in the presence of two additives is a complex process that needs to be studied in detail to rationalize composite preparation. This study aimed to investigate co-precipitation of CaP on different TiO2 nanomaterials (TiNMs), including nanoparticles (TiNPs), nanoplates (TiNPls), nanotubes (TiNTs), and nanowires (TiNWs), in the presence of bovine serum albumin (BSA) and chitosan (Chi). The obtained results have shown that both BSA and Chi inhibited transformation of amorphous to crystalline CaP, even in the presence of TiNMs at concentrations that promoted transformation. Chi proved to be a stronger inhibitor due to its more flexible structure. The presence of BSA and Chi did not influence the composition of the CaP formed as calcium-deficient hydroxyapatite (CaDHA) was formed in all the systems. However, both macromolecules influenced the morphology of the formed CaDHA in different ways depending on the type of TiNM used. BSA and Chi adsorbed on all the TiNMs, as confirmed by zeta potential measurements, but this adsorption reduced the amount of CaP formed on TiNMs only in the case of TiNWs. The obtained results contribute to the understanding of the influence of BSA and Chi on CaP precipitation in the presence of nanomaterials and thus to the rational design of CaP-based multi-composite materials.Keywords: calcium-deficient hydroxyapatite; bovine serum albumin; chitosan; precipitation