The thesis was held on 23. September 2022 at Faculty of Science, Department of Chemistry, University of Zagreb. Supervisor of her thesis was Maja Dutour Sikirić.
We congratulate to you Ina!
Here is an abstract of her thesis:
Calcium phosphates and TiO2 nanomaterials composites are attracting attention as advanced
materials for bone regeneration due to the complementary properties of the components. Current studies
of such composites focus on coating TiO2 nanostructures with calcium phosphate layers to improve their
bioactivity.
The aim of this doctoral thesis was to systematically investigate the biomimetic preparation of
nanocomposites based on calcium phosphate and titania nanomaterials under physiological conditions.
Two methods of nanocomposite synthesis were compared, immersion in simulated body fluid and
precipitation from a suspension. In addition, the influence of biologically active molecules, bovine
serum albumin and chitosan, was determined. To evaluate the in vivo behavior of the prepared
composites, the adsorption and binding parameters of serum albumin were determined, since this protein
is the first to interact with the implant materials after implantation.
The obtained results showed that precipitation from solution is a rapid and versatile method for
preparing TiO2 and calcium phosphate composites, in which no changes in the composition or structure
of the calcium phosphate phase depending on the type of titanium nanomaterials was observed. Such
composites exhibit improved protein adsorption properties, indicating their potential for biomedical
applications.
(186 + XV pages, 90 figures, 34 + XXVII tables, 397 references, original in Croatian)
Thesis deposited in Central Chemical Library, Horvatovac 102A, Zagreb, Croatia and National and
University Library, Hrvatske bratske zajednice 4, Zagreb, Croatia.
Keywords: bovine serum albumin / calcium phosphates / chitosan / nanocomposites / precipitation /
simulated body fluid / titanate nanomaterials